DNA Methylation Testing
DNA Methylation Testing
At Magnolia Personalized Medicine we do DNA testing. The benefits of testing reveal links and underlying causes for insulin sensitivity, cancer risk, neurotransmitter balance, weight gain, cardiovascular health, mental health, bone health and even vitamin D absorption. Then we can work to optimize your genetic expression through diet, nutrition, detox because some genes can be turned off and on.
The DNA Methylation Pathway Profile includes a variety of SNPs (single nucleotide polymorphism):
VDR: (the vitamin D receptor) is a nuclear receptor protein that binds 1,25-dihydroxy vitamin D to activate a signaling molecule that is believed to have important roles in a 3rd of the human genome. Some functions that are known are xenobiotic detoxification.
BHMT: (betaine-homocysteine methylatransferase) is a transferase enzyme that catalyzes the transfer of a methyl group from betaine to homocysteine, which produces methionine. Other enzymatic roles for BHMT is the choline oxidation processes. This enzyme is found in the liver and kidney.
COMT: (catechol-O-methyltransferase) functions in the nerve cells, liver, kidneys, and red blood cells. Its role is to help inactivate 2- and 4-hydroxyestradiols, and catecholamine hormones prior to excretion of bile. COMT is also found in the CNS where its role is the degradation of catecholamine neurotransmitters.
MAO A: (monoamine oxidase type A) its main role is to detoxify biological and xenobiotic amines. This enzyme also degrades neurotransmitters in both the central and peripheral nervous system.
AHCY: (adenosylhomocysteinase) an enzyme that breaks down methionine by converting S-adenosylhomocysteinase into homocysteine. This reaction regulates the methylation of other compounds.
CBS: (cystathionine beta-synthase) this enzyme is responsible for using vitamin B6 to convert serine and homocysteine into cysto thionine which will be later converted into cysteine.
MTHFR: (methylenetetrahydrofolate reductase) enzyme responsible for the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This reaction allows for the conversion of homocysteine to methionine.
MTR: (methionine synthase) enzyme that catalyzes the re-methylation of homocysteine to methionine using the methyl-B-12 as a cofactor.
MTRR: (methionine synthase reductase) responsible for the regeneration of methyl-B-12.
SHMT: (serine hydroxymethyltransferase) responsible for catalyzing the interconversion of glycine to serine.
SUOX: (sulfite oxidase) mitochondrial enzyme responsible for oxidizing sulfites to sulfates. Sulfites are produced by the transsulfuration cycle or from diet.
Tests at Magnolia Personalized Medicine
- Organic Acid Test
- Heavy Metal Test
- Mold Test
- IgG Food Allergy Test
- Glyphosate Test
- Amino Acids Test
- Kryptopyrole Test
- Autism Panel
- Autoimmune Panel
- Hormone Panel
- Mental Health Panel
- Thyroid Panel
- Oxidative Stress Test
- SIBO Breath Test
- Neurotransmitters Test
- Vitamin and Mineral Test
- Cellular Aging Test