Autoimmune conditions

Personalized Approach to autoimmune disease

Testing Sample

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Autoimmune disease is characterized by antibodies attacking own immune system. Many factors have been attributed to imbalance of T –cell  with Th1/Th2 balance and Th17/Treg balance that leads to inflammation. Th1 (T helper cells 1) fight viruses and Th2 up regulates the antibody production. Th17 is implicated in autoimmune inflammation and Treg is inhibitor of inflammation. So one approach is  balancing Th1/Th2, gut healing, nutrient therapy, and herb extract for autoimmunity and inflammation.

Nutritional support

Studies suggest that many nutrients and anti-oxidants are able to support this balance and modulate immunity. For example, it was found that vitamin A upregulates Treg cell and decrease risk of autoimmunity. Through an epidemiological, genetic, and environmental assessment a personalized protocol is created. In certain forms of autoimmunity the optimal levels of vitamin D are absolutely necessary to better function.

Gut Health

Correcting the gut dysbiosis and removing the environmental triggers are important steps. In certain studies,  microbiome like porphyromonas gingivalis and Proteus Mirabilis was strongly associated with RA and Ankylossing spondylitis is associated with Klebsiella pneumonia. Gut healing with elimination of the overgrowth yeast, fungus, and bacteria are at the base of reducing autoimmunity.

Reducing inflammation with botanicals

Autoimmune conditions like R.A, M.S, psoriasis, Ankylosis Spondylitis are characterized by increased inflammation and the purpose is to reduce that inflammation.

References:

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Safari, H., Anani Sarab, G., & Naseri, M. (2019). Artemisia dracunculus L. modulates the immune system in a multiple sclerosis mouse model. Nutritional neuroscience, 1–7. Advance online publication. https://doi.org/10.1080/1028415X.2019.1681742

Lai, C. Y., Su, Y. W., Lin, K. I., Hsu, L. C., & Chuang, T. H. (2017). Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation. Journal of immunology research, 2017, 7807313. https://doi.org/10.1155/2017/7807313

Gupta, S. C., Kismali, G., & Aggarwal, B. B. (2013). Curcumin, a component of turmeric: from farm to pharmacy. BioFactors (Oxford, England), 39(1), 2–13. https://doi.org/10.1002/biof.1079

Jafarzadeh, A., & Nemati, M. (2018). Therapeutic potentials of ginger for treatment of Multiple sclerosis: A review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties. Journal of neuroimmunology, 324, 54–75. https://doi.org/10.1016/j.jneuroim.2018.09.003

Ammon H. P. (2010). Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(11), 862–867. https://doi.org/10.1016/j.phymed.2010.03.003

Rito, Y., Torre-Villalvazo, I., Flores, J., Rivas, V., & Corona, T. (2018). Epigenetics in Multiple Sclerosis: Molecular Mechanisms and Dietary Intervention. Central nervous system agents in medicinal chemistry, 18(1), 8–15. https://doi.org/10.2174/1871524916666160226131842

Chalons, P., Amor, S., Courtaut, F., Cantos-Villar, E., Richard, T., Auger, C., Chabert, P., Schni-Kerth, V., Aires, V., & Delmas, D. (2018). Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages. Nutrients, 10(12), 1856. https://doi.org/10.3390/nu10121856

Cui, C., Wang, J. J., Zhao, J. H., Fang, Y. Y., He, X. F., Guo, H. S., & Duan, C. G. (2020). A Brassica miRNA Regulates Plant Growth and Immunity through Distinct Modes of Action. Molecular plant, 13(2), 231–245. https://doi.org/10.1016/j.molp.2019.11.010

Javadi, B., & Sahebkar, A. (2017). Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. Pharmacological research, 124, 34–42. https://doi.org/10.1016/j.phrs.2017.07.022

Cavalieri, D., Rizzetto, L., Tocci, N., Rivero, D., Asquini, E., Si-Ammour, A., Bonechi, E., Ballerini, C., & Viola, R. (2016). Plant microRNAs as novel immunomodulatory agents. Scientific reports, 6, 25761. https://doi.org/10.1038/srep25761

Shishodia S. (2013). Molecular mechanisms of curcumin action: gene expression. BioFactors (Oxford, England), 39(1), 37–55. https://doi.org/10.1002/biof.1041

Yamamoto, E. A., & Jørgensen, T. N. (2020). Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity. Frontiers in immunology, 10, 3141. https://doi.org/10.3389/fimmu.2019.03141

For a personalized Autoimmune nutrigenetic testing click here: Autoimmune Inflammation Report Sample