Fatigue is a common symptom and sign related to many conditions. First, one must remove barriers from healing and make sure that it is not the lifestyle, diet, stress or medicine prescription that causes it.
Gut medications. Drugs that control nausea, keep you from throwing up, or treat diarrhea can make you sleepy.
Muscle relaxants. Most muscle relaxants don’t work on your muscles directly. Instead, they work on the nerves in your brain and spine to make the muscles relax. Their effects on your nervous system can make you tired. Some common muscle relaxants are carisoprodol (Soma) and cyclobenzaprine (Flexeril).
Opioid pain medications. Opioids act like the chemicals your body makes to control pain, called endorphins. Common ones are fentanyl (Actiq, Duragesic, Fentora), oxycodone and aspirin (Percodan), oxycodone and acetaminophen (Percocet, Roxicet), morphine, oxymorphone (Opana, Opana ER), oxycodone (OxyContin, OxyIR),and hydrocodone and acetaminophen (Lorcet, Lortab, Vicodin).
Seizure or epilepsy medications. Also called anticonvulsants, these medications can work on your brain cells or the chemicals they use to send messages. Some of these drugs are the same ones that treat anxiety, like benzodiazepines. Other common seizure medications are carbamazepine (Tegretol/Tegretol XR/Carbatrol), phenobarbital, phenytoin (Dilantin, Phenytek), topiramate (Topamax), and valproic acid (Depakene, Depakote).